In-vivo bio-molecular interaction studies are essential for our understanding of cellular functioning. Specific in-vivo interactions controlling e.g. cell cycle, differentiation, proliferation or apoptosis events will be discussed in normal healthy and in disease-related situations. This Msc-course will also discuss the fundamental, applied and technical aspects of proteomics and transcriptomics. Based on the novel Cell Observatory facilities, various bio-imaging techniques will be given within a practical course.